Spectrophotometric determination of mexiletine hydrochloride in capsules using bromothymol blue

Aydogmus Z., Cetin S., Tosunoglu S.

TURKISH JOURNAL OF CHEMISTRY, cilt.26, sa.6, ss.839-842, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 6
  • Basım Tarihi: 2002
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.839-842
  • Anahtar Kelimeler: spectrophotometry, mexiletine hydrochloride, bromothymol blue, ion-pair
  • İstanbul Üniversitesi Adresli: Evet

Özet

A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08-10.8 mug.ml(-1) at lambda(max) = 408 nm (r = 0.9999). The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia, method.