Is MMP-7 Gene Polymorphism a Possible Risk Factor for Chronic Obstructive Pulmonary Disease in Turkish Patients


Moğulkoç U., Coskunpinar E., Aynacı E., CAGLAR E., ORTAKOYLU M. G., Ozkan G., ...Daha Fazla

GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.16, sa.6, ss.519-523, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1089/gtmb.2011.0271
  • Dergi Adı: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.519-523
  • İstanbul Üniversitesi Adresli: Evet

Özet

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This study was performed to test the association between MMP-7 (rs155668818) and MMP-12 (rs56184183) polymorphisms in the MMP-7 gene and COPD risk and its severity in the Turkish population. MMP-7 and MMP-12 polymorphisms were genotyped in 85 patients with COPD and 73 healthy control subjects using real-time polymerase chain reaction analysis. There were significant differences in the distribution of MMP-7 genotypes but not in the frequencies of these alleles between COPD patients and controls (p = 0.009, p = 0.102, respectively). The MMP-7 AA genotype was found to be associated with an increased risk of COPD (p = 0.004; odds ratio: 2.576; confidence interval: 1.297-5.119). The lowest values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC in patients with GG homozygosity were determined and these values were statistically significant compared to the control subjects (p < 0.001, p < 0.001, p < 0.001). When the present study groups were analyzed for MMP-12 polymorphism, it was found that all the subjects had wild-type genotype for this polymorphism. These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population.