Antinuclear antibodies in juvenile myoclonic epilepsy

Altindag E., Icoz S., Tuzun E., Durmus H., Uludokumaci A., Demir G. A., ...Daha Fazla

Journal of Neurological Sciences, cilt.26, sa.1, ss.43-48, 2009 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: Journal of Neurological Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.43-48
  • İstanbul Üniversitesi Adresli: Evet

Özet

Juvenile myoclonic epilepsy (JME) is a prototype for idiopathic generalized epilepsy syndrome, which is usually associated with complex inheritance. To delineate if immune mechanisms might also be participating in JME, we screened the sera of 19 JME and 21 healthy control patients for anti-neuronal antibodies using immunohistochemistry and Western blot techniques. JME patients' sera showed relatively but not significantly increased antinuclear/nucleolar antibody incidence and multiple Western blot bands as compared to healthy controls, suggesting humoral immune mechanisms might be participating in JME pathogenesis.