Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schonlein purpura


Yilmaz A. , Emre S., Agachan B., Bilge I., Yilmaz H. , Ergen A., ...More

JOURNAL OF NEPHROLOGY, vol.22, no.6, pp.726-732, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2009
  • Journal Name: JOURNAL OF NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.726-732

Abstract

Background: Henoch-Schonlein purpura (HSP) is a systemic vasculitis; its pathogenesis is still unknown. Oxidative stress may play a role in the pathogenesis of HSP. Paraoxonase1 (PON1) is an antioxidant enzyme. Two polymorphisms have been defined in the coding region of the PON1 gene, Q/R192 and L/M55. In the present study, we aimed to investigate the effect of PON1 gene polymorphisms on the course and renal involvement of HSP in Turkish children.