Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

Moins-Teisserenc, HT; Gadola, SD; Cella, M; Dunbar, PR; Exley, A; Blake, N; Baykal, Can; Lambert, J; Bigliardi, P; Willemsen, M; Jones, M; Buechner, S; Colonna, M; Gross, WL; Cerundolo, V

doi:10.1016/s0140-6736(99)04206-3

Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

Moins-Teisserenc H., Gadola S., Cella M., Dunbar P., Exley A., Blake N., ...More

LANCET, vol.354, no.9190, pp.1598-1603, 1999 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 354 Issue: 9190
Publication Date: 1999
Doi Number: 10.1016/s0140-6736(99)04206-3
Title of Journal : LANCET
Page Numbers: pp.1598-1603

Abstract

Background Granulomatous syndromes, such as Wegener's granulomatosis, are defined according to complex criteria, but the underlying cause is rarely identified. We present evidence for a new aetiology for chronic granulomatous lesions associated with a recessive genetic defect, which is linked to the human leucocyte antigen (HLA) locus.