Low Mmp 9 and VEGF levels predict good oncologic outcome in mid and low rectal cancer patients with neoadjuvant chemoradiation

KURT A., YANAR F., Asoglu O., Balik E., Olgac V., Karanlik H., ...More

BMC CLINICAL PATHOLOGY, vol.12, 2012 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2012
  • Doi Number: 10.1186/1472-6890-12-27
  • Journal Name: BMC CLINICAL PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Istanbul University Affiliated: Yes

Abstract

Background: The aim of this study was to evaluate apoptotic (Bcl-2, Bax expression, caspase-3 activity, and cytochrome-c) and angiogenic (MMP-9 levels and VEGF expression) markers in operable rectal cancer patients who were treated with preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME). Understanding these factors will facilitate the identification of potential pathological responders before treatment, leading to better local control and survival rates.