Analysis of L-MYC gene polymorphism in patients with renal failure outcome to renal transplant

Yiğit, B.; Bozkurt, Nalan; Yaylim, İlhan; Titiz, İzzet; İşbir, Turgay

doi:10.1016/j.transproceed.2006.03.037

Analysis of L-MYC gene polymorphism in patients with renal failure outcome to renal transplant

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Yiğit B., Bozkurt N., Yaylim I., Titiz İ., İşbir T.

TRANSPLANTATION PROCEEDINGS, vol.38, no.5, pp.1267-1269, 2006 (SCI-Expanded)

Publication Type: Article / Article
Volume: 38 Issue: 5
Publication Date: 2006
Doi Number: 10.1016/j.transproceed.2006.03.037
Journal Name: TRANSPLANTATION PROCEEDINGS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1267-1269
Istanbul University Affiliated: Yes

Abstract

Background. Abnormalities of cell numbers and apoptosis have been observed in renal failure. As uncontrolled expression of c-myc is known to induce apoptosis, we thought that polymorphism in the other myc gene, L-myc gene, which is structually similar to c-myc and reported to be expressed in the kidney, may have a role in the induction of apoptosis and thus have role in chronic renal failure. The aim of this study was to investigate the relationship between the distribution of L-myc genotypes and renal failure.