Recombination frequencies of human leukocyte antigen loci in hematological malignancies among Turkish population.

ÇINAR Ç., TEMURHAN S., ÖGRET Y., Akgul S. U., Hayriye Senturk C., BEŞIŞIK S., ...More

International journal of laboratory hematology, vol.43, no.6, pp.1432-1436, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1111/ijlh.13613
  • Journal Name: International journal of laboratory hematology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.1432-1436
  • Keywords: cross over, hematological malignancies, human leukocyte antigen, locus, recombination
  • Istanbul University Affiliated: Yes


Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option with growing performance for leukaemia, aplastic anaemia and genetic disorders. The frequency of MHC (Major Histocompatibility Complex) gene locus recombination is increased at loci close to the telomeres and in the female gender. The aim of the present study is to document the recombination events by pedigree diagrams with the primary goal to determine the frequency of recombination in a different ethnic population from mostly reported studies.