No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.

Hekim N., Ergen A., Yaylim I., Yilmaz H., Zeybek U., Ozturk O., ...More

Cell biochemistry and function, vol.25, no.1, pp.115-7, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1002/cbf.1274
  • Journal Name: Cell biochemistry and function
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.115-7
  • Istanbul University Affiliated: Yes

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. MTHFR is a keyenzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation.