MYELOPEROXIDASE GENE PROMOTOR POLYMORPHYSM IN MOTHERS WHO HAVE A CHILD WITH NEURAL TUBE DEFECT


Dikensoy E., Sever T., PEHLİVAN S., Balat O., Cebesoy F. B., Karcin E.

TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY, cilt.7, sa.2, ss.102-106, 2010 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 2
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.102-106
  • Anahtar Kelimeler: DNA, MPO gene, neural tube defects, PCR-RFLP
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The inflammatory pathway genes myeloperoxidase (MPO) is involved with regulation of inflammation through reactions with hydrogen peroxide (H2O2). The MPO enzyme is expressed abundantly in neutrophils, in which its antimicrobial function converts (H2O2) to the bacterocidal and DNA-damaging hypochlorous acid. Our aim was in this study to investigate whether there is a relationship between MPO gene (rs 2333227) polymorphysm (-463G/A) and neural tube defects.