An HPLC Method for the Determination of Bisoprolol in Human Plasma and its Application to a Pharmacokinetic Study

Ulu S. T., Aydogmus Z.

JOURNAL OF CHROMATOGRAPHIC SCIENCE, cilt.50, sa.7, ss.615-619, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1093/chromsci/bms056
  • Dergi Adı: JOURNAL OF CHROMATOGRAPHIC SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.615-619
  • İstanbul Üniversitesi Adresli: Evet

Özet

A new high-performance liquid chromatographic method is described for the determination of bisoprolol in human plasma. The proposed method was based on the derivatization of bisoprolol with 4-chloro-7-nitro-2,1,3-benzoxadiazole in borate buffer at pH 9.5 to yield a fluorescent product.