Akademik Veri Yönetim Sistemi
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, cilt.37, sa.2, 2026 (SCI-Expanded, Scopus)
In this study, a novel electrochemical sensor was developed for the sensitive and rapid simultaneous determination of riboflavin (B2), pyridoxine (B6) and ascorbic acid (C) in biological samples and dietary supplements using voltammetric techniques. For this purpose, pencil graphite electrode (PGE) was modified with multi-walled carbon nanotubes (MWCNTs) and copper based metal-organic framework (Cu-BTC). The electrochemical and surface characterizations of the sensor were carried out using cyclic voltammetry, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). To optimize the sensor's performance, the effects of electrochemical activation time, MWCNT suspension amount, deposition time, Cu-BTC concentration, cycle number and supporting electrolyte and pH were systematically investigated. Differential pulse voltammetry (DPV) measurements revealed linear detection ranges of 0.1-100 mu M for B2, 5-200 mu M for B6, and 1-1000 mu M for C, with detection limits of 0.021 mu M, 0.011 mu M, and 0.071 mu M, respectively. Additionally, repeatability, reproducibility, stability, and interference studies were conducted. The sensor's applicability in real biological samples and dietary supplements was evaluated, yielding high recovery values. These results confirm that the modified electrode is a reliable and efficient platform for the simultaneous determination of B2, B6, and C.