PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE-27 (PACAP-27) INHIBITS PENTAGASTRIN-STIMULATED GASTRIC-ACID SECRETION IN CONSCIOUS RATS

MUNGAN Z., OZMEN V., ERTAN A., ARIMURA A.

REGULATORY PEPTIDES, cilt.38, sa.3, ss.199-206, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0167-0115(92)90102-z
  • Dergi Adı: REGULATORY PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.199-206
  • İstanbul Üniversitesi Adresli: Evet

Özet

Pituitary adenylate cyclase activating polypeptide (PACAP) is a novel neuropeptide and has two amidated forms, PACAP-27 and PACAP-38. Its chemical structure is similar to that of vasoactive intestinal peptide (VIP). In our previous studies, we found that PACAP has a stimulatory effect on rat exocrine pancreas secretion and an inhibitory effect on rat gastrointestinal motility. These effects of PACAP-27 were greater than those of PACAP-38 and VIP. In the present study, we examined the effect of PACAP-27 on basal and pentagastrin (PG)-stimulated gastric acid secretion in conscious rats and compared its effect with that of VIP.