Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients


Deligezer U., Dalay N.

EXPERIMENTAL AND MOLECULAR MEDICINE, vol.36, no.6, pp.572-575, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1038/emm.2004.73
  • Journal Name: EXPERIMENTAL AND MOLECULAR MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.572-575
  • Istanbul University Affiliated: Yes

Abstract

The X-ray repair cross-complementing group 1 (XRCC1) gene is believed to play an important role in base excision repair and displays genetic polymorphisms. Data on the role of XRCC1 polymorphisms in cancer susceptibility is inconsistent. In the present study, we investigated the effect of two XRCC1 polymorphisms, Arg194Trp and Arg399GIn, on breast cancer risk in a case-control study involving Turkish breast cancer patients and healthy women. Both alleles exhibited a similar distribution among cases and controls leading to lack of any significant association between the XRCC1 polymorphisms and breast cancer risk, either in homozygotes and heterozygotes or combined. The allele frequency of the codon 194 variant was very low in cases and healthy individuals (5.3 and, 3.9%, respectively) compared to that of the variant 399GIn allele (39.7 and 37.4%). Our results do not support evidence for a role of the XRCC1 polymorphism in developing breast cancer.