The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis

Aydın A. F., Vural P., Oruc C. U., Dogru-Abbasoglu S., OZDERYA A., KARADAG B., ...Daha Fazla

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.21, sa.1, ss.181-185, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.intimp.2014.04.023
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.181-185
  • Anahtar Kelimeler: Hashimoto's thyroiditis, Endothelin family, Polymorphism, Inflammation, KAPPA-B, ASSOCIATION, DISEASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Endothelin1 (EDN1) is well established marker of inflammation. The functions of EDN1 are mediated mainly by endothelin receptors type A (EDNRA). The etiopathogenesis of Hashimoto's thyroiditis (HT) remains still elusive although the role of chronic inflammation and subsequent endothelial dysfunction has been established. This study examined firstly the possible association of EDN1 (G5665T and T-1370G) and EDNRA (C+70G and G-231A) single nucleotide polymorphisms (SNPs) with the occurrence of HT, and evaluates the relationship between genotypes and clinical/laboratory manifestation of HT.