Association of Vitamin D Receptor Taq I Polymorphism and Susceptibility to Oral Squamous Cell Carcinoma

Bektas-Kayhan K., Unur M., Yaylim-Eraltan İ., Ergen H. A., Toptas B., Hafiz G., ...More

IN VIVO, vol.24, no.5, pp.755-759, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 5
  • Publication Date: 2010
  • Journal Name: IN VIVO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.755-759
  • Keywords: Vitamin D receptor, polymorphism, oral squamous cell carcinoma, VDR GENE POLYMORPHISMS, PROSTATE-CANCER, BREAST-CANCER, OVARIAN-CANCER, RISK, RELEVANCE
  • Istanbul University Affiliated: Yes

Abstract

Background: It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis. Materials and Methods: The distribution of VDR Tag I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls. Results: There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p<0.001) for oral cancer. Conclusion: These results suggest that the VDR Taq I polymorphism may be associated with susceptibility to OSCC. Female predilection of the OSCC risk in association with VDR gene polymorphism should also be investigated.