Ultrastructural evaluation of intramuscular applied botulinum toxin type A in striated muscles of rats.

Kocaelli H. , Yaltirik M. , Ayhan M., Aktar F., Atalay B. , Yalçın S.

Hippokratia, vol.20, no.4, pp.292-298, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2016
  • Journal Name: Hippokratia
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.292-298
  • Keywords: Botulinum toxin type A, muscular changes, myofibrils, ultrastructure, electron microscopy, atrophy, degeneration


Background: Botulinum toxin type A (BTX-A) is clinically utilized for therapeutic and cosmetic purposes in maxillofacial surgery as well as many other medical specialties. There is no sufficient ultrastructural research about BTX and it is controversial whether BTX-A causes muscle degeneration to some extent, in the course of therapy. The aim of this study was to evaluate the histological effects of BTX-A when injected into masseter and gluteal muscles.