The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer

Arikan S., Gumus A., Kucukhuseyin O., Coskun C., Turan S., Cacina C., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.5, pp.551-558, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2017-0024
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.551-558
  • Keywords: Cluster of differentiation 28 (CD28), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), Gastric cancer, Polymerase chain reaction (PCR), Single nucleotide polymorphism (SNPs), T-LYMPHOCYTE ANTIGEN-4, CERVICAL-CANCER, BREAST-CANCER, RHEUMATOID-ARTHRITIS, EXON-1 POLYMORPHISMS, MULTIPLE-SCLEROSIS, ASSOCIATION, EXPRESSION, SUSCEPTIBILITY, CELLS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Gastric cancer is one of the most common malignancies worldwide. The risk factors for gastric cancer include environmental and genetic factors. Inflammation and the immune system are known to contribute to the development of the gastric cancer. We examined the influence of critical polymorphisms of CTLA-4 and CD28 genes and circulating protein levels on the etiology of gastric cancer.