Cytokine Secretion and Proliferative Capacity of CD4(+) T Cells in Delayed Type Hypersensitivity Reactions due to Ciprofloxacin
TURKISH JOURNAL OF IMMUNOLOGY, cilt.8, sa.3, ss.120-128, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.25002/tji.2020.1339
- Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.120-128
- Anahtar Kelimeler: Allergy, CD4(+) T cells, ciprofloxacin, hypersensitivity, intracellular cytokine, LTT, LYMPHOCYTE-TRANSFORMATION TEST, DRUG HYPERSENSITIVITY, FLUOROQUINOLONES ANALYSIS, SAFETY PROFILE, IFN-GAMMA, DIAGNOSIS, QUINOLONES, RELEASE, TESTS, IL-5
- İstanbul Üniversitesi Adresli: Evet
Özet
Introduction: Ciprofloxacin (CPFX), a frequently prescribed quinolone, may induce cutaneous adverse drug reactions. Delayed type hypersensitivity reactions (DTHR) are often difficult to deal with, therefore, in vitro testing for DTHR is the long-anticipated method for their management. This study aimed to evaluate potential value of lymphocyte transformation t est (LTT) and intracellular cytokine secretion of drug srimulared CD4(+ )T cells in patients with DTHR against ciprofloxacin.