Intrathecal Colistin Induced Chemical Meningitis in a Case of Multi-Drug Resistant Acinetobacter baumannii Meningitis

Benli A. , Yavuz S. , Eraksoy Ö. H.

Print Download PDF Infectious Diseases and Clinical Microbiology, no.1, pp.76-80, 2022 (Other Refereed National Journals)

  • Publication Type: Article / Case Report
  • Publication Date: 2022
  • Doi Number: 10.36519/idcm.2022.98
  • Title of Journal : Print Download PDF Infectious Diseases and Clinical Microbiology
  • Page Numbers: pp.76-80


he possibility of encountering multi-drug resistant Gram-negative bacteria is higher in nosocomial meningitis. These bacteria are clinically important because of their higher mortality rate, and colistin is almost the only treatment option in resistant strains. However, intrathecal administration of colistin can result in chemical meningitis. We reported a case with chemical meningitis during the intravenous sulbactam plus colistin and intrathecal colistin therapy for multi-drug resistant Acinetobacter baumannii meningitis. Cerebrospinal fluid findings of the patient improved after discontinuation of intrathecal colistin therapy. This reversible complication may occur during intrathecal therapy. Discontinuation of intrathecal therapy or reducing the antibiotic dose will be the most appropriate approach to manage such cases