DHRS2 is a potential marker of breast cancer metastasis

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Yaylaz B. S., Ekmekci S. S., ÇINAR S., DENİZ G., ABACI N.

GENE REPORTS, vol.25, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2021
  • Doi Number: 10.1016/j.genrep.2021.101302
  • Journal Name: GENE REPORTS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • Keywords: DHRS2, Migration, MCF7, Breast cancer, RNAi, TARGET GENE, HEP27, MDM2, P53, EXPRESSION, PROTEIN, GROWTH, MEMBER, CELLS
  • Istanbul University Affiliated: Yes


Background: Although breast cancer treatment success has increased, biomarkers are still important. The dehydrogenase/reductase DHRS2 has a role in the metabolic and survival activities of cells. DHRS2 directly binds MDM2 and inhibits the cellular processes of p53. Our study aimed to examine cellular response to inhibit DHRS2 gene expression in the breast cancer cell line MCF7.