The Value of Mitotic Count and Ki67 Proliferation Index in Congenital Mesoblastic Nephroma

APAYDIN E., OZLUK Y., YUKSEL S., ERGINEL B., TUGCU D., CELIK A., ...More

FETAL AND PEDIATRIC PATHOLOGY, vol.35, no.6, pp.376-384, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1080/15513815.2016.1207731
  • Journal Name: FETAL AND PEDIATRIC PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.376-384
  • Keywords: mesoblastic nephroma, pediatric, renal tumor, mitosis, Ki-67, RENAL TUMORS, WILMS-TUMOR, KI-67, NEONATE, TISSUE, FETAL
  • Istanbul University Affiliated: Yes

Abstract

Objective: We aimed to define the histopathologic features and proliferative rate of congenital mesoblastic nephroma (CMN) as a risk factor for recurrence. Methods: Fourteen cases of CMN among 138 registered pediatric renal tumors were retrospectively reviewed. The prognostic impact for mitotic rate and Ki67 index was investigated. Results: There were four (28.6%) classic, six (42.9%) cellular, and four (28.6%) mixed type CMNs, with average Ki-67 counts of 16.75% in the classic CMN, and 53.2% in the tumors with cellular components (both mixed and cellular CMNs). Twelve patients (85.7%) were aged less than six months. Tumors with cellular component showed significantly larger tumor diameter and higher Ki-67 index (p = 0.015 and p = 0.016, respectively). The patient with cellular CMN, whose tumor showed the highest mitotic rate (4.9/HPF), but not the highest Ki67 index (57.4%), died of recurrent disease with distant metastasis. Conclusion: Proliferative markers-mitotic count and Ki67 index-have limited value to predict recurrence or metastasis in CMNs with a cellular component.