Active vitamin D is cardioprotective in experimental uraemia but not in children with CKD Stages 3-5


Schoen A., Leifheit-Nestler M., Deppe J., Fischer D., KARABAY BAYAZIT A., Obrycki L., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.36, no.3, pp.442-451, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1093/ndt/gfaa227
  • Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.442-451
  • Keywords: chronic kidney disease, fibroblast growth factor 23, left ventricular hypertrophy, renin-angiotensin system, vitamin D, LEFT-VENTRICULAR HYPERTROPHY, CHRONIC KIDNEY-DISEASE, GROWTH-FACTOR 23, CARDIAC-HYPERTROPHY, D THERAPY, KLOTHO, PARICALCITOL, CALCIUM, BONE, FIBROBLAST-GROWTH-FACTOR-23

Abstract

Background. Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated fibroblast growth factor 23 (FGF23) and activation of the renin-angiotensin system (RAS). The cardioprotective properties of active vitamin D analogues in this setting are unclear.