An unusual presentation of a chronic lymphocytic leukemia patient with 17p deletion after reduced-intensity transplantation: Richter syndrome and concomitant graft-versus-host disease--case report.

Salihoglu, A.; Ozbalak, Mustafa; Keskin, D.; Tecimer, T.; Soysal, T.; Ferhanoglu, B.

doi:10.1016/j.transproceed.2012.12.001

An unusual presentation of a chronic lymphocytic leukemia patient with 17p deletion after reduced-intensity transplantation: Richter syndrome and concomitant graft-versus-host disease--case report.

Atıf İçin Kopyala

Salihoglu A., Ozbalak M. M., Keskin D., Tecimer T., Soysal T., Ferhanoglu B.

Transplantation proceedings, cilt.45, sa.7, ss.2845-8, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 7
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.transproceed.2012.12.001
Dergi Adı: Transplantation proceedings
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2845-8
İstanbul Üniversitesi Adresli: Evet

Özet

Chronic lymphocytic leukemia (CLL) patients with 17p deletion comprise a challenging subgroup associated with poor overall survival. These patients should be treated with alternative strategies. Reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) can achieve long-term remission in this ultra-high-risk CLL group. Herein, we described a CLL patient with 17p deletion who developed Richter syndrome with extranodal involvement of the liver soon after RIC allo-SCT despite apparent acute graft-versus-host disease.