2-[6-( 4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-( 4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate

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Atıf İçin Kopyala

AKKURT M., Gursoy E., GÜZELDEMİRCİ N., TÜRKTEKİN ÇELİKESİR S., Tahir M. N.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, cilt.68, 2012 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 68
• Basım Tarihi: 2012
• Doi Numarası: 10.1107/s1600536812015371
• Dergi Adı: ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
• İstanbul Üniversitesi Adresli: Evet

Özet

In the title compound, C28H27BrN4O3S2 center dot 2C(2)H(6)O, the cyclohexane ring adopts a chair conformation. The imidazo[2,1-b][1,3]thiazole ring system is essentially planar with a dihedral angle of 1.1 (2)degrees between the thiazole and imidazole rings. The mean plane of this ring system makes dihedral angles of 8.11 (16) and 79.43 (17)degrees, respectively, with the bromo- and hydroxy-substituted benzene rings. In the 5-methyl-1,3-thiazolidin-4-one group, the S atom, the methyl group and the ring C atoms bonded to them are disordered over two sets of sites with refined occupancies of 0.610 (19) and 0.390 (19). The crystal structure features N-H center dot center dot center dot O, O-H center dot center dot center dot O, O-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds and C-H center dot center dot center dot pi interactions. Furthermore, two weak pi-pi stacking interactions [centroid-centroid distances = 3.967 (3) and 3.892 (2) angstrom] are also observed.