Synthesis, characterisation and cytotoxic properties of the N-1,N-4-diarylidene-S-methyl-thiosemicarbazone chelates with Fe(III) and Ni(II)

Bal T., Atasever B., Solakoglu Z., Erdem-Kuruca S., Ulkuseven B.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.42, sa.2, ss.161-167, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.ejmech.2006.09.004
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.161-167
  • Anahtar Kelimeler: S-methyl-thiosemicarbazone, iron chelate, nickel chelate, cytotoxicity, MTT, TRANSITION-METAL-COMPLEXES, ANTI-HIV ACTIVITY, COPPER(II) COMPLEXES, PALLADIUM(II) COMPLEXES, SUBSTITUTED THIOSEMICARBAZONES, ANTIBACTERIAL ACTIVITY, ANTICANCER AGENTS, DERIVATIVES, SEMICARBAZONES, PLATINUM(II)
  • İstanbul Üniversitesi Adresli: Evet

Özet

Reactions of 2-hydroxy-3-methoxy, 2-hydroxy-4-methoxy-benzaldehyde with 3- and 4-methoxy-substituted salicylaidehyde S-methyl-thiosemicarbazones in the presence of FeCl3 and NiCl2 resulted in the corresponding methoxy-substituted N-1,N-4-diarylidene-S-methyl-thiosemicarbazone chelates. Characterisation of the compounds in the [Fe(L)CI] and [Ni(L)] general formula was accomplished by means of elemental analysis, conductivity and magnetic measurements, H-1 NMR, UV-vis, IR and mass spectroscopy. Cytotoxicity and proliferation experiments using K562 chronic myeloid leukemia cell line and ECV 304 human endothelial cell line imply that the iron(111) chelates may have antileukemic effects with 3.5 mu g/dl LD50 dose. (c) 2006 Elsevier Masson SAS. All rights reserved.