Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.

Saruhan-Direskeneli G., HUGHES T., Yilmaz V., Durmus H., ADLER A., Alahgholi-Hajibehzad M., ...Daha Fazla

Clinical immunology (Orlando, Fla.), ss.81-8, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.clim.2016.05.003
  • Dergi Adı: Clinical immunology (Orlando, Fla.)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.81-8
  • Anahtar Kelimeler: Myasthenia gravis, Genome-wide association, MuSK-MG, EOMG, LOMG, ACETYLCHOLINE-RECEPTOR, SUSCEPTIBILITY LOCI, TURKISH PATIENTS, MUSK, ASSOCIATION, DQ, IDENTIFICATION, AUTOANTIBODIES, ANTIBODIES, KINASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

This study aims to investigate genetic susceptibility to early-onset and late-onset anti-acetylcholine receptor antibody positive myasthenia gravis (EOMG and LOMG) and anti-muscle specific kinase antibody positive MG (MuSK-MG) at genome-wide level in a single population. Using a custom-designed array and imputing additional variants and the classical HLA alleles in 398 patients, we detected distinct associations. In EOMG, rs113519545 in the HLA class I region (OR = 5.71 [3.77-8.66], P = 2.24 x 10(-16)), HLA-B*08:01 (OR = 7.04 [3.95-12.52], P = 3.34 x 10(-11)) and HLA-C*07:01 (OR = 2.74 [1.97-3.81], P = 2.07(-9)), in LOMG, rs111256513 in the HLA class II region (OR = 2.22 [1.59-3.09], P = 2.48 x 10(-6)) and in MuSK-MG, an intronic variant within HLA-DQB1 (rs68081734, OR = 5.86, P = 2.25 x 10(-14)) and HIA-DQB1*05:02 (OR = 8.56, P = 6.88 x 10(-13)) revealed the most significant associations for genome-wide significance. Differential genetic susceptibility within the HLA to EOMG, LOMG and MuSK-MG has been established in a population from Turkey. (C) 2016 Elsevier Inc. All rights reserved.