Acute Promyelocytic Leukemia Treated With Idarubicin Complicated by Focal Segmental Glomerulosclerosis

Baris S., Ozdil M., Topal N., Dogru O., Ozdemir N., Sever L., ...More

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.32, no.2, 2010 (SCI-Expanded) identifier identifier identifier


The authors report a 9-year-old boy presenting with a left cerebral ischemic infarction as the first manifestation of acute promyelocytic leukemia. During consolidation chemotherapy, the patient developed nephrotic syndrome and a renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Remission in bone marrow was achieved with chemotherapy, however, new intracranial ischemic areas developed on follow-up. Acute promyelocytic leukemia complicated by FSGS has not been previously reported in children. There may be a relationship between anthracycline treatment and FSGS. Thrombosis could be related with both leukemia and nephrotic syndrome, here thrombosis was the initial symptom, before FSGS was diagnosed.