Infarct Remodeling Process During Long-term Follow-up After Reperfused Acute Myocardial Infarction

Sezer M., Cimen A. O., Aslanger E. K., Yormaz E., Turkmen C., Umman B., ...More

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, vol.338, no.6, pp.465-469, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 338 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1097/maj.0b013e3181b911a2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.465-469
  • Keywords: Acute myocardial infarction, Infarct size, Left ventricular function, Coronary artery disease, Infarct healing, TC-99M SESTAMIBI, SIZE, RAT, EXPANSION, CELLS
  • Istanbul University Affiliated: Yes


Background: After acute myocardial infarction (AMI), the recovery of perfusion in infarct area may lead to significant spontaneous infarct size (IS) reduction during the subsequent period. The natural course of infarct-healing process after reperfusion therapy has not been fully elucidated. In this study, we investigated the time course of the spontaneous infarct-healing process in patients with reperfused AMI. Methods and Results: Fifty-two patients with AMI who underwent primary percutaneous intervention were included. IS was measured with single-photon emission tomography using Bull's eye method at 4th day, at 5th, and at 10th months. IS was expressed as a percentage of the total myocardium. IS decreased by 33.6% at 5th month when compared with 4th day IS (from 26.3% +/- 18.8% to 17.5% +/- 12.9%, P < 0.001, n = 44). At 10th month, mean IS decreased by 21% when compared with 5th month IS (from 15.89% +/- 12.65% to 12.53% +/- 9.35%, P = 0.007, n = 31) and 49% when compared with 4th day IS (24.02% +/- 17.67% to 12.53% +/- 9.35%, P < 0.001). Conclusion: Significant endogenous recovery of perfusion in the infarct area occurs at the long term in patients with reperfused AMI, Infarct healing is a dynamic and ongoing process and decrease in IS continues long term after reperfused AMI.