A patient with encephalitis associated with NMDA receptor antibodies

SANSING L. H., Tuzun E., KO M. W., BACCON J., LYNCH D. R., DALMAU J.

NATURE CLINICAL PRACTICE NEUROLOGY, cilt.3, sa.5, ss.291-296, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1038/ncpneuro0493
  • Dergi Adı: NATURE CLINICAL PRACTICE NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.291-296
  • Anahtar Kelimeler: catatonia, NMDA receptor antibodies, ovarian teratoma, paraneoplastic encephalitis, psychosis, PARANEOPLASTIC LIMBIC ENCEPHALITIS, SYMPTOMS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background A 34-year-old woman presented with headache, feverish sensation and anxiety, rapidly followed by homicidal ideation, aggressive agitation, seizures, hypoventilation, hyperthermia and prominent autonomic instability requiring intubation and sedation. She developed episodes of hypotension and bradycardia with periods of asystole lasting up to 15 seconds. Upon weaning off sedation, her eyes opened but she was unresponsive to stimuli. There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm.