Secondary metabolites from Euphorbia helioscopia and their vasodepressor activity


BARLA A., Birman H. , Kultur S. , OKSUZ S.

TURKISH JOURNAL OF CHEMISTRY, vol.30, no.3, pp.325-332, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2006
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.325-332

Abstract

From the aerial parts of Euphorbia helioscopia L. ( Euphorbiaceae), a jatrophane diterpene ester, 5,11-jatrophadiene-3-benzoyloxy-7,9,14-tri-acetyloxy-15-ol and 2 lupane derivatives, lup-20( 29)-ene-3-acetate and lup-20( 29)-ene-3-palmitate, together with common triterpenoids of Euphorbiaceae, 24-methylene cycloartanol, 24-methylenecycloart-3-one, cycloartanol, and stigmast-4-ene-3-one were isolated. The last compounds, lup-20( 29)-ene-3-acetate, 24-methylene cycloartanol, 24-methylenecycloart-3-one, cycloartanol, and stigmast-4-ene-3-one, were isolated for the first time from E. helioscopia. The fractions and the isolates were tested for their vasodepressor effects using Wistar Albino rats, and 5,11-jatrophadiene-3-benzoyloxy-7,9,14-tri-acetyloxy-15-ol, lup-20( 29)-ene-3-acetate, and stigmast-4-ene-3-one were found to possess relevant activity. The structures of all of the compounds were identified with high field spectroscopic methods. The detailed spectroscopic data of compound 1 is given in the present study.