Cox-2 gene variants in migraine

Dasdemir S., Çetinkaya Y., Gencer M., Ozkok E., Aydin M., Cakmakoglu B.

GENE, cilt.518, sa.2, ss.292-295, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 518 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2012.12.110
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.292-295
  • Anahtar Kelimeler: Migraine, Cox-2, Polymorphism, CYCLOOXYGENASE-2, EXPRESSION, ASSOCIATION, POLYMORPHISMS, ROFECOXIB, INDUCTION, VITILIGO, RISK, PAIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Migraine is a multifactorial and complex disorder, and any clear diagnostic marker to assess the status of the migraineurs has not been established, yet. Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine. Thus, COX-2 regulation is important in the pathogenesis and treatment of migraine. We prospectively investigated COX-2-765G -> C and COX-2-1195A -> G gene polymorphisms which may account for an increased risk of migraine.