Satellite 2 repeat DNA in blood plasma as a candidate biomarker for the detection of cancer

Özgür E., Mayer Z., Keskin M., Yörüker E. E., Holdenrieder S., Gezer U.

CLINICA CHIMICA ACTA, cilt.514, ss.74-79, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 514
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.cca.2020.12.008
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.74-79
  • Anahtar Kelimeler: Cancer, Biomarker, Liquid biopsy, Satellite DNA, Human satellite 2, CIRCULATING TUMOR DNA, GENOME
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and aim: Currently, cancer biomarkers are associated with low diagnostic performance, and the notion of using cell-free DNA (cfDNA) as a surrogate cancer biomarker is a subject of ongoing research efforts. Pericentromeric satellite repeats were shown to expand in tumor cells. Here, we hypothesized that the increased release of satellite DNA into the circulation might be a basis for developing a biomarker for the detection of cancer.