Satellite 2 repeat DNA in blood plasma as a candidate biomarker for the detection of cancer


Özgür E. , Mayer Z., Keskin M. , Yörüker E. E. , Holdenrieder S., Gezer U.

CLINICA CHIMICA ACTA, vol.514, pp.74-79, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 514
  • Publication Date: 2021
  • Doi Number: 10.1016/j.cca.2020.12.008
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.74-79
  • Keywords: Cancer, Biomarker, Liquid biopsy, Satellite DNA, Human satellite 2, CIRCULATING TUMOR DNA, GENOME

Abstract

Background and aim: Currently, cancer biomarkers are associated with low diagnostic performance, and the notion of using cell-free DNA (cfDNA) as a surrogate cancer biomarker is a subject of ongoing research efforts. Pericentromeric satellite repeats were shown to expand in tumor cells. Here, we hypothesized that the increased release of satellite DNA into the circulation might be a basis for developing a biomarker for the detection of cancer.