The acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock

Almac E., Aksu U., Bezemer R., Jong W., Kandil A., YÜRÜK K., ...More

RESUSCITATION, vol.83, no.9, pp.1166-1172, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1016/j.resuscitation.2012.02.011
  • Journal Name: RESUSCITATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1166-1172
  • Keywords: Colloid, Crystalloid, Resuscitation, Renal oxygenation, Hemorrhagic shock, Microcirculation, MAJOR ABDOMINAL-SURGERY, LACTATED RINGERS SOLUTION, FLUID RESUSCITATION, HYPERCHLOREMIC ACIDOSIS, METABOLIC-ACIDOSIS, ENDOTHELIAL ACTIVATION, TRANSFUSION TRIGGER, EXPERIMENTAL SEPSIS, HYPERTONIC SALINE, CRITICALLY-ILL
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Fluid resuscitation therapy is the initial step of treatment for hemorrhagic shock. In the present study we aimed to investigate the acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock. We hypothesized that acetate-balanced solutions would be superior in correcting impaired renal perfusion and oxygenation after severe hemorrhage compared to unbalanced solutions.