Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants


Gürsoy A., Karali N. L., Büyüktimkin S., Demirayak Ş., Ekinci A., Özer H.

FARMACO, cilt.51, sa.6, ss.437-442, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 6
  • Basım Tarihi: 1996
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.437-442
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation,of isatin with aryoxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazone-2-indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, H-1-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against. pentylenentetrazole induced seizures.