Comparative study on the effect of aspirin, TP receptor antagonist and TxA(2) synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery.

Ozen, Gülsev; Aljesri, Khadija; Abdelazeem, Heba; Norel, Xavier; Turkyılmaz, Gulsum; Turkyılmaz, Saygın; Topal, Gokce

doi:10.1016/j.lfs.2021.120073

Comparative study on the effect of aspirin, TP receptor antagonist and TxA(2) synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery.

Atıf İçin Kopyala

Ozen G., Aljesri K., Abdelazeem H., Norel X., Turkyılmaz G., Turkyılmaz S., ...Daha Fazla

Life sciences, cilt.286, ss.120073, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 286
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.lfs.2021.120073
Dergi Adı: Life sciences
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.120073
Anahtar Kelimeler: TxA(2), Aspirin, TP receptor antagonist, TxS inhibitor, Saphenous vein, Internal mammary artery, Vascular tone, PROSTAGLANDIN E-2, INDUCED CONTRACTION, THROMBOXANE, REACTIVITY, LATANOPROST, U46619
İstanbul Üniversitesi Adresli: Evet

Özet

Aims: Thromboxane (TxA(2)) is synthesized from arachidonic acid (AA) via thromboxane synthase (TxS) enzyme and induces vasoconstriction via TP receptor. Our aim is to compare the effects of aspirin, TxS inhibitor and TP receptor antagonist on vascular reactivity of bypass grafts (saphenous vein and internal mammary artery).