Investigation of Cytotoxic Effects of Some Novel Synthesized Iminothiazolidinone Derivatives on HeLa Cell Line (CCL2)


Tuğcu F., TOPÇUL M. R., ÇETİN İ., ÜNLÜ Y. S., GERÇEK Y. C., MORGİL H., ...More

IUFS JOURNAL OF BİOLOGY, vol.1, no.75, pp.15-33, 2016 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 75
  • Publication Date: 2016
  • Journal Name: IUFS JOURNAL OF BİOLOGY
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.15-33
  • Istanbul University Affiliated: Yes

Abstract

In medicinal chemistry, the thiazolidinones are practical framework which can be leaned as a pharmacophore in a large diversity of biologically active compounds. Furthermore, they build up the base of antibacterials, anti-convulsant, antitumorals, antivirals, anti-diabetic, anti-inflammatory, anti-HIV compounds in many other therapeutic agents. In this study the genotoxic and cytotoxic effects of some novel synthesized iminothiazolidinone derivatives (Compound A-E) on HeLa (3) cell line (CCL2) which arising from human cervical carcinoma were studied. Accordingly, kinetics parameters of proliferation rate, mitotic and the labeling index were determined upon the application of the iminothiazolidinone derivatives. 1 x 10-6, 5 x 10-6, 10 x 10-6 M concentrations of the derivatives were implemented for 72 hours to find out the optimum concentrations and the result was explicated by reproduction rate analysis. Parameters of mitotic and labeling index of the cells which were treated with the optimum concentrations of the uniquely synthesized iminothiazolidinone derivatives for 0-72 hours were calculated. The results indicated that the tested compounds caused a remarkable decrease in the propagation of HeLa cell cultures and the 10 x 10-6 M concentration was found to be the most effective concentration of the iminothiazolidinone derivatives in terms of reducing the reproduction rate. Drugs can be obtained from these derivatives will offer a promising treatment modality in cervix carcinoma in the future.