Chronic mild stress-induced anhedonia in rats is coupled with the upregulation of inflammasome sensors: a possible involvement of NLRP1

Ozkartal C. S., ARICIOĞLU F., Tuzun E., Kucukali C. I.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.28, no.3, pp.236-244, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1080/24750573.2018.1426694
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.236-244
  • Keywords: Stress, depression, NOD-like receptor, NLRP, inflammasome, MAJOR DEPRESSIVE DISORDER, NOD-LIKE RECEPTORS, ANIMAL-MODELS, PREFRONTAL CORTEX, MOUSE MODEL, ACTIVATION, ANTIDEPRESSANT, MICE, BEHAVIOR, CYTOKINES
  • Istanbul University Affiliated: Yes

Abstract

INTRODUCTION: NOD-like receptors containing pyrin domain (NLRP) are cytosolic receptors belong to innate immune system and function as sensing bodies for danger signals by forming inflammasome complex which in turn produces caspase-1-mediated interleukin (IL)-1 beta and IL-18 proinflammatory cytokines. Latest findings indicate that NLRP3 inflammasome mainly located in microglia cells in central nervous system (CNS) is linked to depression pathophysiology. However, another important CNS inflammasome, the neuronal NLRP1 inflammasome, has not been addressed in psychological stress or depression, yet. Therefore, the aim of the present study was to investigate the possible involvement NLRP1 inflammasome together with NLRP3 in chronic unpredictable mild stress (CUMS), a well-validated animal model of depression in rats.