Y-90 Microsphere Radioembolization Dosimetry Y-90 Mikroküre Radyoembolizasyon Dozimetri Kılavuzu
Nuclear Medicine Seminars, vol.11, no.1, pp.39-47, 2025 (Scopus)
- Publication Type: Article / Review
- Volume: 11 Issue: 1
- Publication Date: 2025
- Doi Number: 10.4274/nts.galenos.2025.03521
- Journal Name: Nuclear Medicine Seminars
- Journal Indexes: Scopus, Academic Search Premier
- Page Numbers: pp.39-47
- Keywords: Y-90 dosimetry, Y-90 microsphere dosimetry, Y-90 radioembolization treatment dosimetry
- Open Archive Collection: AVESIS Open Access Collection
- Istanbul University Affiliated: Yes
Abstract
The need for dosimetric calculations has arisen to enhance the therapeutic efficacy of Yttrium-90 (Y-90) microsphere therapy, determine tumor absorbed dose threshold values, and accurately identify lung tolerance dose thresholds and liver toxicity thresholds. In microsphere therapies, there are three different dosimetry approaches: standard dosimetry, multicompartment dosimetry, and voxel-based dosimetry. Dosimetric procedures are generally performed using Technetium-99m macroaggregated albumin. However, dosimetry based on scintigraphic images obtained from positron emission tomography/computed tomography (CT) or single photon emission computerized tomography/CT after Y-90 administration is also feasible.