Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis

Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Baki M., OZDERYA A., KARADAG B., ...Daha Fazla

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.28, sa.1, ss.521-524, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.intimp.2015.07.019
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.521-524
  • Anahtar Kelimeler: Hashimoto's thyroiditis, Transforming growth factor beta 1, Polymorphism, Autoimmune, Leu10 Pro, Arg 25 Pro, REGULATORY T-CELLS, TRANSFORMING-GROWTH-FACTOR-BETA-1 GENE, AUTOIMMUNE-THYROIDITIS, RHEUMATOID-ARTHRITIS, CYTOKINE GENOTYPES, TGF-BETA, TGF-BETA-1, DISEASE, GROWTH-FACTOR-BETA-1, SEQUENCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.