Serum microRNA expression in pregnancies with preeclampsia

Gunel T., Zeybek Y. G., Akcakaya P., Kalelioglu I., Benian A., Ermis H., ...Daha Fazla

GENETICS AND MOLECULAR RESEARCH, cilt.10, sa.4, ss.4034-4040, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4238/2011.november.8.5
  • Dergi Adı: GENETICS AND MOLECULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4034-4040
  • Anahtar Kelimeler: MicroRNA, Preeclampsia, Non-invasive prenatal diagnosis, MATERNAL PLASMA, MESSENGER-RNA, BIOMARKERS, IDENTIFICATION, DEATH
  • İstanbul Üniversitesi Adresli: Evet

Özet

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.