Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs radiotherapy alone in stage IV (>=N2, M0) undifferentiated nasopharyngeal carcinoma: A positive effect on progression-free survival

Cvitkovic, E; ESCHWEGE, F; RAHAL, M; DOSEN, .; MERSİC, Z; KRAJİNA, Z; ARMAND, JP; BOUHRİS, J; TubianaMathieu, M; Fountzilas, G; KOSMİDİS, PA; PRASAD, U; GANESAN, S; EL GUEDDARİ, B; BACHOUCHİ, M; Mansouri, A; Oliveira, J; Raposo, J; WİERZBİCKİ, R; LİANES, P; PENA, C; ONAT, Haluk; ALTUN, Musa; BENHAMOU, E; DUCOURTİEUX, M; AZLI, N; FANDİ, A; TAAMMA, A; BOSQ, J; KLİJANİENKO, J; SİGAL, R; HONG, WK; VOKES, EE; CLARK, JR; LE FLOCH, O; BERNİER, J

doi:10.1016/s0360-3016(96)80007-1

Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs radiotherapy alone in stage IV (>=N2, M0) undifferentiated nasopharyngeal carcinoma: A positive effect on progression-free survival

Atıf İçin Kopyala

Cvitkovic E., ESCHWEGE F., RAHAL M., DOSEN .., MERSİC Z., KRAJİNA Z., ...Daha Fazla

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, cilt.35, sa.3, ss.463-469, 1996 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 35 Sayı: 3
Basım Tarihi: 1996
Doi Numarası: 10.1016/s0360-3016(96)80007-1
Dergi Adı: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.463-469
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Our Phase II trial using bleomycin, epirubicin, and cisplatin (BEG) protocol in the treatment of locoregionally advanced undifferentiated nasopharyngeal carcinoma (UCNT) patients has shown encouraging results with high objective response, disease-free survival, and overall survival rates. To establish the value of this BEC regimen as neoadjuvant chemotherapy, we initiated in 1989 a large international Phase III trial. It compares three cycles of EEC followed by radiotherapy to radiotherapy alone.