Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia

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Erbilgin Y., Hatirnaz Ng O., Can I., Firtina S., Kucukcankurt F., Karaman S., ...Daha Fazla

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, cilt.43, sa.5, ss.1093-1103, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/ijlh.13513
  • Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1093-1103
  • Anahtar Kelimeler: ALL, biomarker, gene expression, LEF1, prognosis
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer including leukemia. Here, we investigated LEF1 isoform expression and genomic variations in acute lymphoblastic leukemia (ALL).