ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer

Akisik E., Yazici H., Dalay N.

MOLECULAR BIOLOGY REPORTS, cilt.38, sa.1, ss.343-348, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s11033-010-0113-3
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.343-348
  • Anahtar Kelimeler: Polymorphism, ARLTS1, MDM2, RAD51, Breast cancer, SINGLE NUCLEOTIDE POLYMORPHISM, ACCELERATES TUMOR-FORMATION, ACUTE MYELOID-LEUKEMIA, PROMOTER POLYMORPHISM, SNP309 POLYMORPHISM, MUTATION CARRIERS, NO ASSOCIATION, OVARIAN-CANCER, REPAIR GENES, DNA-DAMAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Genetic factors that contribute to the risk of breast cancer are largely not known and association studies have revealed several genes with low penetrance risk alleles for breast cancer. Analysis of these genes may provide important information on the risk factors affecting carcinogenesis. Variations in the ARLTS1, RAD51 and MDM2 genes have been associated with increased risk of different cancer types but for breast cancer the results are not consistent. In this study we investigated the role of the allelic variants in candidate genes acting in the tumor suppressor, DNA repair and p53 pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease. Presence of the polymorphic variants were investigated by amplification of the corresponding regions and restriction fragment length polymorphism analysis. Genotype and allele frequencies in the patients were significantly different for all three variants. Our results indicate that the polymorphic variants might affect individual susceptibility towards breast cancer.