Atıf İçin Kopyala
Karali N., AKDEMİR A., Goktas F., Elma P. E., Angeli A., Kizilirmak M., ...Daha Fazla
BIOORGANIC & MEDICINAL CHEMISTRY, cilt.25, sa.14, ss.3714-3718, 2017 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
25
Sayı:
14
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Basım Tarihi:
2017
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Doi Numarası:
10.1016/j.bmc.2017.05.029
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Dergi Adı:
BIOORGANIC & MEDICINAL CHEMISTRY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.3714-3718
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Anahtar Kelimeler:
Carbonic anhydrase, Isatin, 2-Indolinone, Docking, IN-VITRO ANTICANCER, ISATIN-BETA-THIOSEMICARBAZONES, MULTIDRUG-RESISTANT CELLS, ANTITUBERCULOSIS ACTIVITY, DERIVATIVES, ANALOGS, AGENTS, CYTOTOXICITY, COMPLEXES, LIGANDS
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İstanbul Üniversitesi Adresli:
Evet
Özet
Human carbonic anhydrases IX and XII are upregulated in many tumors and form a novel target for new generation anticancer drugs. Here we report the synthesis of novel 2-indolinone derivatives with the sulfonamide group as a zinc binding moiety. Enzyme inhibition assays confirmed that the compounds showed selectivity against hCA IX and XII over the widely distributed off-targets hCA I and II. Molecular modelling studies were performed to suggest modes of binding for these compounds. (C) 2017 Elsevier Ltd. All rights reserved.