A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients with Prolactinoma.

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Sahin S., Sudutan T., Kavla Y., Durcan E., Özogul Y. Y., Poyraz B. C., ...More

The Journal of clinical endocrinology and metabolism, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2022
  • Doi Number: 10.1210/clinem/dgac718
  • Journal Name: The Journal of clinical endocrinology and metabolism
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, Gender Studies Database, MEDLINE, Veterinary Science Database
  • Istanbul University Affiliated: Yes


Context: Dopamine agonist (DA)induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly

recognized in patients with prolactinoma.

Objective: We aimed to examine the genetic component of the underlying mechanism of DA-induced ICD.

Methods: Patients with prolactinoma receiving dopamine agonist (cabergoline) treatment were included in the study. These patients were divided into 2 groups: patients who developed ICD due to DA and patients who did not. Patients were evaluated for polymorphisms of the DRD1DRD3COMTDDCGRIN2BTPH2OPRK1OPRM1SLC6A4SLC6A3HTR2A genes.

Results: Of the 72 patients with prolactinoma using cabergoline, 20 were diagnosed with ICD. When patients with and without ICD were compared according to genotype frequencies, OPRK1/rs702764, DRD3/rs6280, HTR2A/rs6313, SLC6A4/rs7224199, GRIN2B/rs7301328, TPH2/rs7305115, COMT/rs4680, DRD1/rs4532 polymorphisms significantly increased in patients with DA-induced ICD.

Conclusion: Our results show that multiple neurotransmission systems affect DA-induced ICD in patients with prolactinoma.