Comparison of epidural analgesia combined with general anesthesia and general anesthesia for postoperative cognitive dysfunction in elderly patients.

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Orhun G., Sungur Z., Koltka K., Karadeniz M., Yavru H. A., Gurvit H., ...More

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, vol.26, no.1, pp.30-36, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.14744/tjtes.2019.04135
  • Journal Name: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.30-36
  • Keywords: Cognitive dysfunction, elderly, epidural analgesia, general anesthesia, postoperative pain, REGIONAL ANESTHESIA, NONCARDIAC SURGERY, NEUROINFLAMMATION, DELIRIUM, IMPAIRMENT, PROPOFOL, SCREEN
  • Istanbul University Affiliated: Yes

Abstract

BACKGROUND: Cognitive dysfunction in the early postoperative course is common for the elderly population. Anesthetic management may affect postoperative cognitive decline. Effective analgesia, early recovery and modulation of the stress response are advantages of neuraxial blocks. This study aims to compare the effects of general anesthesia and the combination of general anesthesia with epidural analgesia for postoperative cognitive dysfunction (POCD). We hypothesized that neuraxial block combined with general anesthesia (GA) would have a favorable influence on POCD prevention.