Akademik Veri Yönetim Sistemi
Southern Clinics of Istanbul Eurasia, cilt.35, sa.2, ss.191-195, 2024 (Hakemli Dergi)
Objective: There are numerous diagnostic, biological, and histological manifestations of salivary gland tumors, each of which offers concerns and difficulties in terms of diagnosis, grading, categorization, and therapy. The purpose of this study was to evaluate and compare the immunohistochemical expression of Bcl-2, caspase-3, and GSTP in benign and malignant salivary gland tumors, as well as how they are connected to a variety of clinicopathological variables. Methods: A total of 61 cases of buffered formalin-fixed, paraffin-embedded tissues from previously identified cases of benign and malignant salivary gland tumors were included in this study. The immunohistochemistry staining process was carried out according to the manufacturer’s recommendations, employing polyclonal anti-Bcl-2, anti-caspase-3, and anti-GST antibodies. Results: The correlation between mean tumor diameter and Bcl-2 expression was shown to be statistically significant (rs=0.258, p<0.05). In pleomorphic adenoma tumor tissues, there were statistically significant correlations between the expression levels of Bcl-2 and caspase-3 (rs=0.66, p<0.01), Bcl-2 and GST (rs=0.61, p<0.01), and caspase-3 and GST (rs=0.73, p<0.01) when tumor types were compared. The tissues with pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma had the highest staining intensity of Bcl-2 expression, while the lowest staining intensity of GSTP expression was observed. Conclusion: It seems probable to draw the conclusion that salivary gland tumors that resist apoptosis have elevated levels of Bcl-2 expression. The prognosis for salivary gland tumors may be poor due to the positive correlation between tumor diameter and high Bcl-2 expression.