Relationship between the 1359 G/A polymorphism of the Central Cannabinoid Receptor 1 (CNR1) gene and susceptibility to cannabis addiction in a Turkish population

ISIR A. B., NACAK M., OĞUZKAN BALCI S., PEHLİVAN S., KUL S., Benlier N., ...Daha Fazla

AUSTRALIAN JOURNAL OF FORENSIC SCIENCES, cilt.47, sa.2, ss.230-238, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/00450618.2014.936895
  • Dergi Adı: AUSTRALIAN JOURNAL OF FORENSIC SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-238
  • Anahtar Kelimeler: 1359 G/A CNR1 polymorphism, cannabinoid receptor gene, DNA polymorphism, forensic science, INDUCED DOPAMINE RELEASE, CB1 RECEPTOR, KNOCKOUT MICE, SUBSTANCE DEPENDENCE, ALCOHOL DEPENDENCE, NUCLEUS-ACCUMBENS, MALE TWINS, ASSOCIATION, RISK, SAMPLE
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study, we investigate the existence of a possible genetic association between 1359 G/A polymorphism of the Central Cannabinoid Receptor 1 (CNR1) Gene CNR1 (p.Thr453Thr; rs1049353) single nucleotide polymorphism (SNP) and cannabis addiction. DNA samples used in this work are purified from venous leukocytes of 145 unrelated Turkish cannabis-dependent subjects and 140 Turkish control subjects. No significant difference is observed in genotype or allele frequencies of CNR1 1359 G/A polymorphism between these two groups. We also compared CNR1 1359 G/A polymorphism allele frequency distribution in our healthy Turkish population with other healthy populations. The comparison of healthy Turkish subjects with the healthy subjects from English-Irish, Chinese, European-American, African-American, Italian, German and Japanese populations revealed significant differences in allele frequencies. Data indicate that the 1359 G/A CNR1 polymorphism does not contribute to susceptibility to cannabinoid addiction in Turkish subjects. To the best of our knowledge, this is the first study on 1359 G/A CNR1 polymorphism in the Turkish population.