Quetiapine Fumarate Extended-release Tablet Formulation Design Using Artificial Neural Networks

Ozcelik E., Mesut B., Aksu B., Ozsoy Y.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.3, ss.213-221, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.97720
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-221
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: This design study was implemented within the scope of the quality by design approach, which included the "International Conference on Harmonization" guidelines. We evaluated the quality of a modified-release tablet formulation of quetiapine fumarate, which was designed using artificial neural networks (ANN), and determined a new formulation that was similar to the reference product.